发明名称 |
Pharmaceutical combinations for the treatment of stroke and traumatic brain injury |
摘要 |
This invention relates to methods of treating traumatic brain injury (TBI) or hypoxic or ischemic stroke, comprising administering to a patient in need of such treatment an NR2B subtype selective N-methyl-D-aspartate (NMDA) receptor antagonist in combination with either: (a) a sodium channel antagonist; (b) a nitric oxide synthase (NOS) inhibitor; (c) a glycine site antagonist; (d) a potassium channel opener; (e) an AMPA/kainate receptor antagonist; (f) a calcium channel antagonist; (g) a GABA-A receptor modulator (e.g., a GABA-A receptor agonist); or (h) an antiinflammatory agent. This invention also relates to methods of treating hypoxic or ischemic stroke comprising administering to a patient in need of such treatment an NMDA receptor antagonist in combination with a thrombolytic agent.
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申请公布号 |
US6821985(B2) |
申请公布日期 |
2004.11.23 |
申请号 |
US20010947878 |
申请日期 |
2001.09.06 |
申请人 |
PFIZER, INC. |
发明人 |
CHENARD BERTRAND L.;MENNITI FRANK S.;SALTARELLI MARIO D. |
分类号 |
C07D211/52;A61K31/4453;A61K31/451;A61K31/453;A61K38/16;A61K38/43;A61K38/48;A61K38/49;A61K45/00;A61K45/06;A61P7/02;A61P9/00;A61P9/10;A61P25/00;C07D405/04;(IPC1-7):A61K31/44;A61K31/445 |
主分类号 |
C07D211/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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