COMPOSITIONS USEFUL FOR TRANSFERRING THERAPEUTICALLY ACTIVE SUBSTANCES INTO A TARGET CELL, AND THEIR USE IN GENE THERAPY

摘要

The present invention relates to a composition which is intended for transferring at least one therapeutically active substance into the interior of a target cel l, characterized in that it comprises a mixture of at least one therapeutically active substance and at least one polar compound which is selected from a specific group of aprotic polar compounds. The therapeutically active substance is preferably a polynucleotide, and the polar compound is DPSO, which improves the ability of the polynucleotide to be transfected into the interior of the cells. The compositions according to the invention can be used as a diagnostic therapeutic, prophylactic or vaccinal medicament for treating the human or animal body by means of gene therapy.