发明名称 |
Method for producing D-allo -isoleucine |
摘要 |
A method for producing D-allo-isoleucine is provided. The method comprises converting L-isoleucine to the corresponding hydantoin. A mixture containing the hydantoin is contacted with a D-hydantoinase to stereoselectively hydrolyze any D-allo-isoleucine hydantoin in the mixture to the corresponding N-carbamoyl-D-allo-isoleucine. The N-carbamoyl-D-allo-isoleucine is decarbamoylated to produce D-allo-isoleucine. Preferably the contacting of the hydantoin with a D-hydantoinase is carried out under conditions permitting the simultaneous epimerization of the chiral center at C-5 of the hydantoin.
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申请公布号 |
US6822116(B2) |
申请公布日期 |
2004.11.23 |
申请号 |
US20020165495 |
申请日期 |
2002.06.07 |
申请人 |
BIOCATALYTICS, INC. |
发明人 |
ROZZELL J. DAVID;ZHU DUNMING |
分类号 |
C07C227/20;C07C229/08;C07D233/74;C12P13/06;C12P41/00;(IPC1-7):C07C229/00 |
主分类号 |
C07C227/20 |
代理机构 |
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主权项 |
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地址 |
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