Production of formulation containing micro-dosed active agent, e.g. ointment containing calcitriol, by encapsulating active agent in vaseline before introduction into mixer to avoid toxicity risks

摘要

Production of a formulation (A) containing a micro-dosed active agent (I) involves: (a) weighing (I) into a vessel lined with vaseline; (b) encapsulating (I) using further vaseline; (c) introducing the vessel, including (I) and the vaseline, into a mixer; and (d) allowing (I) to diffuse in the mixer.