发明名称 |
Crystal modification of torasemide |
摘要 |
The present invention relates to the characterization of a new crystal modification III of torasemide, to a process for the preparation thereof by the use of controlled acidifying of alkaline solutions of torasemide with inorganic or organic acids with or without addition of a crystal seed, to its use as a raw material for the preparation of the crystal modification I of torasemide and of pharmaceutically acceptable salts of torasemide as well as to pharmaceutical forms containing this new crystal modification III of torasemide.
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申请公布号 |
US2004229919(A1) |
申请公布日期 |
2004.11.18 |
申请号 |
US20040871667 |
申请日期 |
2004.06.21 |
申请人 |
PLIVA HRVATSKA D.O.O. |
发明人 |
FILIC DARKO;DUMIC MILJENKO;DANILOVSKI ALEKSANDAR;KLEPIC BOZENA;FISTRIC INES;ORESIC MARINA;MIKULCIC JASNA HORVAT |
分类号 |
A61K9/20;A61K31/44;A61K31/4409;A61P7/02;A61P9/10;A61P9/12;A61P11/06;A61P27/06;A61P35/00;C07D213/53;C07D213/71;C07D213/74;(IPC1-7):C07D213/62 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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