发明名称 |
Composition and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis and abnormal cell proliferation |
摘要 |
Compositions and methods are disclosed for the therapeutic use of an atonal-associated nucleic acid or amino acid sequence. Also, an animal heterozygous for an atonal-associated gene inactivation is also disclosed having at least one atonal-associated nucleic acid sequence replaced by insertion of a heterologous nucleic acid sequence used to detect expression driven by an atonal-associated promoter sequence, wherein the inactivation of the atonal-associated nucleic acid sequence prevents expression of the atonal-associated gene.
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申请公布号 |
US2004231009(A1) |
申请公布日期 |
2004.11.18 |
申请号 |
US20040860373 |
申请日期 |
2004.06.03 |
申请人 |
ZOGHBI HUDA Y.;BELLEN HUGO J.;BERMINGHAM NESSAN A.;HASSAN BASSEM;BEN-ARIE NISSIM |
发明人 |
ZOGHBI HUDA Y.;BELLEN HUGO J.;BERMINGHAM NESSAN A.;HASSAN BASSEM;BEN-ARIE NISSIM |
分类号 |
A01K67/027;A01K67/033;A61K35/76;A61K38/00;A61K48/00;A61P19/02;A61P25/00;A61P27/16;A61P35/00;C07K14/46;C07K14/465;C07K14/47;C07K14/705;C12N5/08;C12N5/10;C12N15/09;C12N15/12;C12Q1/68;G01N33/15;G01N33/50;(IPC1-7):A01K67/027;A01K67/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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