Antibodies for inhibiting blood coagulation and methods of use thereof

摘要

Disclosed is a method for treating blood coagulation in a mammal that has or is suspected of having septic shock syndrome. In one embodiment, the method includes administering to the mammal an effective amount of an antibody that binds tissue factor in a way that excludes Factor X (FX) binding. The invention has a wide range of useful applications including use to inhibit unwanted blood coagulation associated with sepsis.