发明名称 |
Chiral salt resolution |
摘要 |
A method for resolving enantiomers of a compound containing the structure of the formula: wherein R<4 >or R<5 >may contain one or more asymmetric centers, by mixing a racemic mixture of enantiomers of a compound, containing the structure of said formula; in a solvent, with a resolving compound having a defined stereospecificity, to form a solution and with said resolving agent being capable of binding with at least one but not all of said enantiomers to form a precipitate, containing said at least one of said enantiomers in stereospecific form and collecting either the precipitate and purifying it or collecting the solution with contained other of said enantiomers and recrystallizing the enantiomer contained in said solution.
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申请公布号 |
US2004229923(A1) |
申请公布日期 |
2004.11.18 |
申请号 |
US20040869101 |
申请日期 |
2004.06.16 |
申请人 |
WILCOX GLENN E.;FLANAGAN MARK E.;MUNCHHOF MICHAEL J.;VRIES TON;KOECHER CHRISTIAN |
发明人 |
WILCOX GLENN E.;FLANAGAN MARK E.;MUNCHHOF MICHAEL J.;VRIES TON;KOECHER CHRISTIAN |
分类号 |
A61K;A61K31/505;A61K31/519;A61K45/00;A61P;A61P1/04;A61P3/10;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P25/00;A61P25/28;A61P29/00;A61P35/00;A61P35/02;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07B57/00;C07D;C07D211/56;C07D487/04;(IPC1-7):C07D213/26;A61K31/165 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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