发明名称 |
MICROSPHERE-BASED COMPOSITION FOR PREVENTING AND/OR REVERSING NEW-ONSET AUTOIMMUNE DIABETES. |
摘要 |
<p>AS-oIigonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to reverse an autoimmune diabetes condition in NOD mice in vivo. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.</p> |
申请公布号 |
MX2009001226(A) |
申请公布日期 |
2009.03.20 |
申请号 |
MX20090001226 |
申请日期 |
2007.08.06 |
申请人 |
BAXTER INTERNATIONAL INC. |
发明人 |
NICK GIANNOUKAKIS;LARRY R. BROWN;KIMBERLY A. GILLIS |
分类号 |
A61K31/7088;A61K38/28;A61P3/10;A61P37/00 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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