4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES

摘要

Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykin in B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.