| 摘要 |
PROBLEM TO BE SOLVED: To actually alleviate type 2 diabetes-like symptoms, by administering a compound having AGEs inhibitory action on an SHR/NDmc-cp rat. SOLUTION: This evaluation method for a protein modifier production inhibitor has a process of administering a substance to be tested to the SHR/NDmc-cp rat, before and/or after type 2 diabetes-like simptoms are developed, a process for measuring the production level of a saccharified final product in the SHR/NDmc-cp rat and a process for evaluating that the substance to be tested has protein modifier production inhibitory action, when the substance to be tested has a saccharified final product producing level inhibitory action. By this method, a compound usable in the treatment and/or prevention of the disease caused by the production of AGEs can be screened. COPYRIGHT: (C)2005,JPO&NCIPI
|
