摘要 |
Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, t, R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>7</SUP>, R<SUP>9</SUP>, R<SUP>10</SUP>, R<SUP>11 </SUP>and R<SUP>12 </SUP>are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
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