Granule modulating hydrogel system

摘要

A naproxen once-a-day matrix tablet is described which is based on a compressed mixture of a controlled release component of said tablet that contains: p1 (i) substantially homogeneous granules of naproxen or a pharmaceutically acceptable salt of naproxen and an organic acid which are prepared by a granulation process which uses a pharmaceutically acceptable film forming material as the binding material; (ii) a pharmaceutically acceptable hydrogel forming polymer; and (B) a coating on said compressed mixture which consists essentially of naproxen or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable film forming composition which allows for immediate release of naproxen.