PROCESS FOR THE PRODUCTION OF OXANDROLONE

摘要

The present invention relates to a process for the synthesis of oxandrolone from mestanolone. The process comprises the steps of: (a) oxidizing mestanolone to form 17beta -hydroxy-17alpha -methyl-5 -androst-1-en-3-one; (b) hydroxylating the 17beta - hydroxy-17alpha -methyl-5alpha -androst-1-en-3-one to form 1alpha , 2alpha , 17beta -trihydroxy-17alpha - methylandrostan-3-one; (c) cleaving the 1alpha , 2alpha , 17beta -trihydroxy-17alpha -methylandrostan-3- one to form 17beta -hydroxy-17alpha -methyl-1-oxo-1,2,-seco-A-nor-5 -androstan-2-oic acid; and (d) reducing the 17beta -hydroxy-17 -methyl-1-oxo-1,2,-seco-A-nor-5alpha -androstan-2-oic acid to form oxandrolone.