METHODS AND COMPOSITIONS FOR DIAGNOSIS AND THERAPY OF PARKIN-ASSOCIATED DISORDERS

摘要

Methods and compositions are provided for the diagnosis and treatment of Parkin-associated disorders such as certain cancers and non-cancerous proliferative diseases. Compounds comprising Parkin protein and biologically active fragments, derivatives, or homologs thereof, as well as nucleotide sequences encoding these compounds, can be used in the diagnosis and treatment of Parkin-associated disorders. Also provided are methods and compositions for the diagnosis of a predisposition for developing a Parkin-associated disorder.