发明名称 |
TGF-BETA ANTAGONISTS COMBINED WITH RENIN-ANGIOTENSIN-ALDOSTERON-SYSTEM ANTAGONISTS FOR TREATING RENAL INSUFFICIENCY |
摘要 |
<p>The disclosure provides methods for treating, preventing, and reducing risk of occurrence of renal insufficiency in mammals. The disclosed methods include administering to a subject susceptible to, or afflicted with, renal disorder therapeutically effective amounts of a TGF-beta antagonist and a renin-angiotensin-aldosterone system (RAAS) antagonist so as to maintain desirable levels of renal function. The populations treated by the methods of the invention include but are not limited to patients suffering or at risk for the development of renal insufficiency, such as those afflicted with type I or type II diabetes, hypertension, (auto)immune disease, systemic fibrosis, etc.</p> |
申请公布号 |
WO2004098637(A1) |
申请公布日期 |
2004.11.18 |
申请号 |
WO2004US13677 |
申请日期 |
2004.04.30 |
申请人 |
GENZYME CORPORATION;LEDBETTER, STEVEN;BENIGNI, ARIELA;REMUZZI, GIUSEPPE |
发明人 |
LEDBETTER, STEVEN;BENIGNI, ARIELA;REMUZZI, GIUSEPPE |
分类号 |
A61K39/395;A61K45/06;A61P13/12;(IPC1-7):A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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