RADIOSENSITIVITY-ENHANCING AGENT HAVING HISTON-DEACETYLATION ENZYME INHIBITORY ACTIVITY AND METHOD FOR IDENTIFYING EFFECTIVE OPTIMUM DOSE OF THE SAME AGENT

摘要

PROBLEM TO BE SOLVED: To improve the sensitivity of cancer cells which originally have a low sensitivity to the irradiation of a radiation by a pre-treatment with a histon deacethylation enzyme inhibitor, and thereby providing a new radiation sensitizer. SOLUTION: The enhancement of apoptosis caused by the irradiation of the radiation by pre-treating cancer cells with the histon deacethylation enzyme acting by a different mechanism from that of conventional anti-cancer agents depending on cell division is ascertained. Thereby, the expansion of adaptation and applicability of a radiation utilizing the histon deacethylation enzyme inhibitor is improved. COPYRIGHT: (C)2005,JPO&NCIPI