METHOD FOR PRODUCTION OF (3R, 3aS,6aR)-HEXAHYDROFURO[2,3-b]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1- BENZYL-2-HYDROXYPROPYLURETHANE

摘要

FIELD: medicine. ^ SUBSTANCE: production of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylurethane is carried out with application of intermediate compound 4-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(isobutyl)benzenesulfonamide. (3R,3aS,6aR)- hexahydrofuro [2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylurethane is applicable, in particular as inhibitor of HIV protease. ^ EFFECT: simplified process due to exclusion of necessity to extract phenyl ethynyl. ^ 14 cl, 9 ex