CONTEXT SENSITIVE PARALLEL OPTIMIZATION OF ZINC FINGER DNA BINDING DOMAINS
摘要
The present invention relates to methods of identifying multi-finger Zf polypeptides that bind to a sequence of interest. Zf polypeptides identified using the methods described herein can have affinity and specificity for their target sites that is superior to those produced by alternative methods.
申请公布号
WO2004099366(A2)
申请公布日期
2004.11.18
申请号
WO2003US34010
申请日期
2003.10.23
申请人
THE GENERAL HOSPITAL CORPORATION;MASSACHUSSETTS INSTITUTE OF TECHNLOGY;JOUNG, KEITH J.;PABO, CARL