DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS

摘要

The invention relates to a compound having general formula (I), wherein: A = N or CR2; R2 = H, F, OH, CN, CF3, C1-6-alkyl, C1-6-alcoxy; n = 2 or 3 and m = 2 when A = N; n = 1, 2 or 3 and m = 1 or 2 when A = CR2; B = covalent bond or C1-8-alkylene; R1 = optionally-substituted heteroaryl; R3 = CHR4CONHR5; R4 = H or C1-6-alkyl; R5 = H, C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-Cl-6-alkylene; the base, the acid addition salt, the hydrate or the solvate thereof. The invention also relates to the application thereof in therapeutics.