发明名称 |
PRODRUGS CLEAVABLE BY CD26 |
摘要 |
<p>The present invention provides a new prodrug technology and new prodrugs in order to increase the solubility, to modulate plasma protein binding or to enhance the biovailability of a drug. In the present invention the prodrugs are conjugates of a therapeutic compound and a peptide (eg tetrapeptide or hexapeptide) wherein the conjugate is cleavable by dipeptidyl-peptidases, more preferably by CD26, also known as DPPIV (dipeptidyl aminodipeptidase IV). The present invention furthermore provides a method of producing said prodrugs, to enhance brain and lymphatic delivery of drugs and/or to extend drug half-lives in plasma.</p> |
申请公布号 |
WO2004098644(A1) |
申请公布日期 |
2004.11.18 |
申请号 |
WO2004BE00069 |
申请日期 |
2004.05.10 |
申请人 |
K.U. LEUVEN RESEARCH & DEVELOPMENT;BALZARINI, JAN |
发明人 |
BALZARINI, JAN |
分类号 |
A61K38/00;A61K47/48;C07D493/04;C07H15/252;C07K5/06;C07K5/062;C07K5/065;C07K5/068;C07K5/072;C07K5/083;C07K5/103;C07K5/11;C07K5/113;C07K7/06;C07K9/00;(IPC1-7):A61K47/48;C07D473/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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