发明名称 Process for producing dihydro-2H-pyran derivatives
摘要 Disclosed is a process for preparing dihydro-2H-pyran derivatives of formula I: wherein R1 and R2 are defined herein. The process of the invention provides the compound of formula I in concise cascade reactions and in one pot. The compound of formulae I prepared by the process of the invention and its further transformed derivatives are useful for making pharmaceutical composition for the treatment of proliferative diseases.;
申请公布号 US9346780(B2) 申请公布日期 2016.05.24
申请号 US201314431945 申请日期 2013.10.10
申请人 OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION 发明人 Chouthaiwale Pandurang V.;Tanaka Fujie
分类号 A61K31/35;C07D309/16;C07D309/28;C07D309/30;C07D317/30;C07C201/14;C07D407/04;C07D241/44;C07D243/02;C07D307/54;C07C205/55 主分类号 A61K31/35
代理机构 Chen Yoshimura LLP 代理人 Chen Yoshimura LLP
主权项 1. A compound of formula II: wherein R1 is alkyl, cycloalkyl, aryl, heterocycloalkyl or heteroaryl, which is optionally substituted with one or more substituent selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, nitro, cyano, halogen, hydroxyl, mono- or polyhalo alkyl, mono- or polyhalo alkoxy and phenyl; R2 is alkyl or benzyl; and R4 is hydroxyl or halogen;or racemate, enantiomer, diastereomer, mixture thereof, or pharmaceutically acceptable salt thereof.
地址 Okinawa JP