IMPROVEMENT IN THE PRODUCTION OF IMIDAZOLE DERIVATIVES AND NOVEL INTERMEDIATES OF THE DERIVATIVES

摘要

The invention provides an improvement in the production of imidazole derivatives including histamine H3 agonist immepip and histamine H3 antagonist VUF4929. Desired imidazole derivatives can be easily obtained in high yield by using novel intermediates represented by the general formula (I): wherein R<1> is an amino-protecting group; R<2> and R<3> are each independently hydrogen, lower alkyl, or hydroxy-(lower alkyl); R<4> is lower alkyl, halogenated lower alkyl, or substituted or unsubstituted phenyl; and A is C1-3 alkylene.