VECTOR CONSTRUCTS FOR GENE-THERAPY MEDIATED RADIONUCLIDE THERAPY OF UNDIFFERENTIATED AND MEDULLARY THYROID CARCINOMAS AND NON-THYROIDAL TUMOURS AND THE METASTASES THEREOF

摘要

The invention relates to vector constructs, comprising vector DNA which includes regulatory sequences, the NIS gene coding for the sodium/iodide symporter, the TPO gene coding for thyroidal peroxidase and use thereof for production of a medicament/diagnostic for treatment/diagnosis of tumour disease states, whereby treatment occurs before or concurrent with a radionuclide therapy, in particular, with iodine-131, or astatine-211. The invention further relates to use of two or several vector constructs for production of a medicament/diagnostic for treatment/diagnosis of tumour disease states.