Use of EGFR Pathway Inhibitors to Increase Immune Responses to Antigens

摘要

This disclosure relates to using EGFR pathway inhibitors in combination with compositions comprising an antigen to increase, elicit, or improve an antigen or vaccine-induced immune response. In certain embodiments, the EGFR pathway inhibitor is administered under conditions such that memory cells to the antigen are formed in a subject. In certain embodiments, the composition is a vaccine. In certain embodiments, the EGFR pathway inhibitor and vaccine are administered to the skin epidermis or dermis.

主权项

1. A method of vaccinating a subject comprising administering a vaccine in combination with a epidermal growth factor receptor (EGFR) pathway inhibitor to a subject in need thereof.