Alternatively spliced isoforms of cysteine protease cathepsin K (CTSK)

摘要

The present invention features nucleic acids and polypeptides encoding two novel splice variant isoforms of cysteine protease cathepsin K (CTSK). The polynucleotide sequences of CTSKsv1.1 and CTSKsv1.2 are provided by SEQ ID NO 1 and SEQ ID NO 3, respectively. The amino acid sequences for CTSKsv1.1 and CTSKsv1.2 are provided by SEQ ID NO 2 and SEQ ID NO 4, respectively. The present invention also provides methods for using CTSKsv1.1 and CTSKsv1.2 polynucleotides and proteins to screen for compounds that bind to CTSKsv1.1 and CTSKsv1.2, respectively.