发明名称 |
Method and Composition for the Treatment of Angiogenesis |
摘要 |
We have now discovered that partially deglycosylated vitamin D binding protein (DBP-maf) is anti-tumorigenic not wholly via an immune mechanism but in part via an antiangiogenic mechanism. Accordingly, the present invention relates to use of DBP-maf in the treatment of diseases associated with increased or abnormal angiogenesis and/or endothelial cell differentiation. Preferably, the DBP-maf is administered to the patient by sustained release or in pulses. Pulse therapy is not a form of discontinuous administration of the same account of a composition over time, but comprises administration of the same dose of the composition at a reduced frequency or administration of reduced doses.
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申请公布号 |
US2004224877(A1) |
申请公布日期 |
2004.11.11 |
申请号 |
US20030275414 |
申请日期 |
2003.06.13 |
申请人 |
PIRIE-SHEPHERD STEVEN;KISKER OLIVER;ONIZUKA SHINYA;RAY RAHUL;NARASIMHA SWAMY;FOLKMAN M. JUDAH |
发明人 |
PIRIE-SHEPHERD STEVEN;KISKER OLIVER;ONIZUKA SHINYA;RAY RAHUL;NARASIMHA SWAMY;FOLKMAN M. JUDAH |
分类号 |
A61K45/00;A61K31/59;A61K31/592;A61K38/00;A61K38/21;A61P1/00;A61P1/16;A61P9/00;A61P9/10;A61P11/00;A61P13/00;A61P13/08;A61P13/12;A61P15/00;A61P17/02;A61P17/06;A61P19/00;A61P19/02;A61P21/00;A61P25/00;A61P27/02;A61P27/06;A61P29/00;A61P35/00;A61P37/00;(IPC1-7):A61K38/17 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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