发明名称 |
VORRICHTUNG UND VERFAHREN ZUR BESTIMMUNG VON MOLEKÜLEN MITTELS TRANSISTOREN |
摘要 |
Binding of a molecule to a molecular receptor is sensed using a transistor having a gate located at a binding site. The channel conductance of the transistor is modified by a charge associated with the molecule when the molecule binds with the molecular receptor. A modified electrical characteristic of the transistor which results is sensed to sense the binding event. Electric field enhancement is provided by applying a voltage to the gate. A second sensing transistor can be coupled to the sensing transistor to form a differential pair. The differential pair allows for enhancing and sensing of differential binding events. |
申请公布号 |
DE69727042(T2) |
申请公布日期 |
2004.11.11 |
申请号 |
DE1997627042T |
申请日期 |
1997.08.07 |
申请人 |
MOTOROLA, INC. |
发明人 |
SHIEH, CHAN-LONG;ACKLEY, E. |
分类号 |
C12N15/09;C12Q1/68;G01N27/00;G01N27/327;G01N27/414;G01N33/543;(IPC1-7):G01N27/414 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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