LIGAND-EXCHANGE FUNCTIONAL ANTIGENS, AND USE OF SAME IN PHARMACEUTICAL VACCINE COMPOSITIONS

摘要

The present invention provides novel modified, hydroxyl replacing antigens, vaccines including the modified antigens, and related methods. Modified antigens include at least one hydroxyl replacing moiety capable of replacing a surface hydroxyl group of a metal hydroxide adjuvant by ligand exchange to form a metal hydroxide adjuvant/antigen complex.