METHOD AND APPARATUS FOR DETERMINING MYOCARDIAL ELECTRICAL RESITUTION AND CONTROLLING EXTRA SYSTOLIC STIMULATION

摘要

A system and method are provided for controlling extra systolic intervals during extra systolic stimulation delivered to effectively produce post-extra systolic potentiation (PESP) to improve hemodynamic function for the treatment of cardiac mechanical insufficiency. Controlling the interval is based on measurements of the electrical restitution properties of myocardial tissue. A parameter related to the action potential duration is measured from an electrical signal received from the heart during extra systolic stimulation at different intervals. An electrical restitution condition is determined from the measured action potential duration related parameter. An operating interval is set based on the measured electrical restitution. Methods for controlling the interval further include setting the operating ESI based on electrical restitution and/or the mechanical effect of PESP on post-extra systoles. Methods for controlling the interval include setting the operating interval based on a measure of electrical restitution and a measure of mechanical restitution.