摘要 |
The invention relates to a pharmaceutical composition for the treatment of psoriasis and other skin diseases. The inventive composition comprises 17-clobetasol propionate and a hydroxyl derivative of progesterone having formula (I) wherein: R6 denotes H or methyl; R11 denotes H or hydroxyl; and R17 denotes H or hydroxyl, but R11 and R17 cannot be H simultaneously. Preferably, said composition is administered as a lotion with: 0.05-2% 17-clobetasol propionate; 0.3-1% of (I); a solvent selected from among ethanol, isopropanol and mixtures thereof; 40% cosolvent selected from among propylene glycol, glycerine, sorbitol and mixtures thereof; and 20% water. In the ideal lotion, the solvent is ethanol and the cosolvents are approximately: 35% propylene glycol, 5% glycerine and 20% water. The invention affords the following advantages: longer interval between recurrences and fewer local secondary effects. Moreover, the inventive composition can be used for the treatment of psoriasis.
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