PROTEIN COMPLEXES OF THE TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) SIGNALLING PATHWAY

摘要

The present invention relates to the protein complexes of the Tumor necrosis factor -alpha- (TNF-alpha)-signalling pathway. component proteins of the said complexes, fragments and derivatives of the component proteins, and antibodies specific to the complexes. The present invention also relates to methods for use of the complexes of the TNF-alpha-signalling pathway and their interaction in, inter alia, screening, diagnosis, and therapy, as well as to methods of preparing the complexes. Furthermore the invention relates to siRNA-oligonucleotides having a significant effect on the expression of the proteins of the complexes of the invention.