发明名称 |
ADENOVIRUS-MEDIATED GENE TRANSFER TO CARDIAC OR VASCULAR SMOOTH MUSCLE |
摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for specific gene expression to cardiac or vascular smooth muscle. <P>SOLUTION: Disclosed is a process for expressing a gene product in the cardiac muscle cell, comprising the steps of (a) infusing an adenovirus vector construct including a coding sequence encoding the gene product into the blood flow of an coronary artery or coronary sinus perfusing the cardiac muscle cell, wherein the vector drives expression of the gene product in the cardiac muscle cell; and (b) obtaining expression of the gene product in the cardiac muscle cell. <P>COPYRIGHT: (C)2005,JPO&NCIPI |
申请公布号 |
JP2004313198(A) |
申请公布日期 |
2004.11.11 |
申请号 |
JP20040167855 |
申请日期 |
2004.06.04 |
申请人 |
ARCH DEVELOPMENT CORP |
发明人 |
LEIDEN JEFFREY M;BARR ELIAV |
分类号 |
C12N15/09;A61K31/7088;A61K35/76;A61K38/00;A61K38/22;A61K45/00;A61K48/00;A61P9/10;C07K14/47;C12N5/10;C12N15/12;C12N15/861;C12P21/00;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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