| 摘要 |
<p>A preventive or therapeutic agent for intraocular vascularization disease, comprising a crystallin inhibitory substance as an active ingredient. As the crystallin inhibitory substance, there can be mentioned, for example, an antisense oligonucleotide or double helical RNA, such as siRNA composed of an RNA strand having the nucleotide sequence CCUGAAGGAGACUGGUAUGTT (SEQ ID No. 1) and a complementary stand thereof. The thus obtained drug composition is effective in the inhibition of intraocular vascularization and hence can find application to intraocular vascularization diseases, such as diabetic retinopathy and retinopathy of prematurity.</p> |
