HALOGENATED TRIPTOLIDE DERIVATIVES AS IMMUNOMODULATORS AND ANTICANCER AGENTS

摘要

Compounds having the structure (I): are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR<1>R<2> is selected from CHOH, C=O, CHF, CF2 and C(CF3)OH; CR<6> and CR<13> are selected from CH, COH and CF; CR<7>R<8>, CR<9>R<10> and CR<11>R<12> are selected from CH2, CHOH, C=O, CHF and CF2; and CR<3>R<4>R<5> is selected from CH3, CH2OH, C=O, COOH, CH2F, CHF2 and CF3; such that: at least one of R<1>-R<13> comprises fluorine; no more than two of CR<3>R<4>R<5>, CR<6>, CR<7>R<8>, CR<9>R<10>, CR<11>R<12>, and CR<13> comprises fluorine or oxygen; and, when CR<1>R<2> is CHOH, CR<3>R<4>R<5> is not CH2F.