发明名称 |
Tumour-specific P450 protein |
摘要 |
<p>The discovery that CYP1B1 protein is detectable in a wide range of human cancers of different histogenetic types, but is not detectable in non-cancerous tissues, gives rise to diagnostic methods for detecting tumours based on this protein as a marker, and to the possibility of tumour therapies involving the protein. A diagnostic method may include the steps of: (a) obtaining from a patient a tissue sample to be tested for the presence of cancer cells: (b) producing a prepared sample in a sample preparation process; (c) contacting the prepared sample with an antibody that reacts with human CYP1B1 protein; and (d) detecting binding of the antibody to CYP1B1 protein in the prepared sample.</p> |
申请公布号 |
EP1475639(A2) |
申请公布日期 |
2004.11.10 |
申请号 |
EP20040019264 |
申请日期 |
1996.09.25 |
申请人 |
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN;UNIVERSITY OF MASSACHUSETTS |
发明人 |
MELVIN, WILLIAM THOMAS;MURRAY, GRAEME IAN;BURKE, MICHAEL DANNY;GREENLEE, WILLIAM FRANK |
分类号 |
A61K31/00;A61K38/00;A61K38/44;A61K45/00;A61P35/00;C07K14/80;C12N9/02;C12Q1/26;G01N33/573;G01N33/574;(IPC1-7):G01N33/574 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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