发明名称 |
Process for preparing N-[3-(3-cyanopyrazolo[1,5-A]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide (zaleplon) |
摘要 |
<p>The present invention provides a process for the production of N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon), an active ingredient that is approved for the treatment of insomnia. The process involves reacting N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethylacetamide or a salt thereof with 3-amino-4-cyanopyrazole or a salt thereof under acidic conditions in a reaction medium comprising a mixture of water and a water-miscible organic compound.</p> |
申请公布号 |
CZ20033544(A3) |
申请公布日期 |
2004.11.10 |
申请号 |
CZ20030003544 |
申请日期 |
2002.06.12 |
申请人 |
BIOGAL GYOGYSZERGYAR RT |
发明人 |
KORODI FERENC;FEHER ERIKA;MAGYAR ERIKA |
分类号 |
A61K31/519;A61P25/20;A61P25/22;C07D487/04;(IPC1-7):C07D487/04 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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