发明名称 |
Method of inhibiting retroviral integrase |
摘要 |
Disclosed is a method of inhibiting retroviral integrase in a subject in need of such treatment. The method comprises administering to the subject an effective retroviral integrase inhibiting amount of a bis-benzimidazole compound such as bis[5-amidino-2-benzimidazolyl]methane, 1,2-bis[5-amidino-2-benzimidazolyl]ethane, 1,2-bis[5-amidino-2-benzimidazolyl]ethene or a pharmaceutically acceptable salt thereof. A method for combatting retroviral infections is also disclosed.
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申请公布号 |
US6815461(B1) |
申请公布日期 |
2004.11.09 |
申请号 |
US19940185079 |
申请日期 |
1994.01.20 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
DYKSTRA CHRISTINE C.;SWANSTROM RONALD I.;TIDWELL RICHARD R. |
分类号 |
C07D235/20;A61K31/415;A61K31/4184;A61P31/12;A61P43/00;(IPC1-7):A61F31/415 |
主分类号 |
C07D235/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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