NOVEL CHALCONE-BASED DERIVATIVE HAVING INHIBITING EFFECT OF INTERLEUKIN-5

摘要

PURPOSE: A novel chalcone-based derivative is provided, which has an interleukin-5 inhibiting effect and a chronic allergic inflammation curing effect and is a low molecule and a non-peptide material. CONSTITUTION: The novel chalcone-based derivative represented by the formula(1) is produced by condensing a compound represented by the formula(2) and a compound represented by the formula(3) in an alcohol solvent in the presence of a base, wherein the alcohol solvent is a C1-C5 alcohol and the base is sodium hydroxide or potassium hydroxide. In the formulas, R1 and R2 are benzyloxy, cyclohexyl methoxy, hydrogen, or hydroxy and R3 is hydroxy or -COOH.