CYCLOHEXYL ISOFLAVONONE DERIVATIVE INHIBITING IL-5 ACTIVITY TO ALLEVIATE ASTHMA SYMPTOM

摘要

PURPOSE: Provided is a cyclohexyl isoflavonone derivative inhibiting IL-5 activity. The derivative inhibits the introduction of eosinophil which is an inflammatory cell causing asthma into the airway, and improves the airway sensitivity to alleviate asthma symptom. CONSTITUTION: The isoflavonone derivative of the formula (1) inhibiting IL-5 activity is provided, wherein R1 is cyclohexylmethoxy, hydrogen or hydroxy; R2 is cyclohexylmethoxy, hydrogen or hydroxy; R3 is hydroxy, -OCH2COOCH3, -OCH2COOH. The method for preparing the isoflavonone derivative of the formula (1) comprises the steps of: reacting a compound of the formula (2) with thallium nitrate trihydrate in lower alcohol to prepare a compound of the formula (1-1); reacting the compound of the formula (1-1) with potassium carbonate and methyl chloroacetate in an organic solvent to prepare a compound of the formula (1-2); and reacting the compound of the formula (1-2) with potassium hydroxide in an organic solvent to prepare a compound of the formula (1-3).