| 摘要 |
PROBLEM TO BE SOLVED: To provide a pharmaceutical useful for treating melatoninergic system-related disease (such as circadian rhythm disorder, sleep disorder, anxiety disorder, mental disease, Parkinson's disease, Alzheimer's disease, cancer, ovulation disorder, diabetes and obesity). SOLUTION: This pharmaceutical composition contains a compound of, for example, N-[2-(6-methoxy-4-isoquinolinyl)ethyl]acetamide, N-[2-(6-methoxy-4-isoquinolinyl)ethyl]propanamide, N-[2-(6-methoxy-4-isoquinolinyl)ethyl]cyclopropanecarboxamide, 4-(6-methoxy-4-isoquinolinyl)-N-methylbutanamide, N-[2-(6-methoxy-2-phenyl-1,2,3,4-tetrahydro-4-isoquinolinyl)ethyl]acetamide or N-[2-(2-benzyl-6-methoxy-1,2,3,4-tetrahydro-4-isoquinolinyl)ethyl]acetamide, or an addition salt of the compound with a pharmaceutically acceptable acid. COPYRIGHT: (C)2005,JPO&NCIPI
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