DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G-PROTEIN COUPLED RECEPTOR PROSTAGLANDIN E2 EP3 III (PROSTAGLANDIN E2 EP3 III)

摘要

The invention provides a human prostaglandin E2 EP3 III which is associated with the cardiovascular diseases, hematological diseases, urological diseases, metabolic diseases, endocrinological diseases, gastroenterological diseases, cancer and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, urological diseases, metabolic diseases, endocrinological diseases, gastroenterological diseases, cancer and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of prostaglandin E2 EP3 III as well as pharmaceutical compositions comprising such compounds.