| 摘要 |
The present invention relates to co-extruded pharmaceutical compositions and dosage forms comprising an adverse agent, such as an opioid antagonist, whic h can be sequestered. The pharmaceutical compositions and dosage forms diversi on of a dosage form containing an active pharmaceutical agent, such as an opioi d. The present invention also relates to methods of treating a patient with suc h a dosage form, as well as kits containing such a dosage form with instructio ns for using the dosage form to treat a patient. The present invention further relates to a process for the preparation of such pharmaceutical compositions and dosage forms comprising co-extrusion of a core comprising an adverse age nt and a sheath. |
