发明名称 |
VERFAHREN ZUR HERSTELLUNG BASISCHER ADDITIONSSALZE EINES ANTIBIOTIKUMS MIT EINER ANORGANISCHEN SÄURE UND OXALAT-ZWISCHENPRODUKTE |
摘要 |
<p>The present invention provides: an industrially-excellent and novel process for producing a basic antibiotic.inorganic acid salt, for example, an excellent production process for producing a hydrochloride thereof industrially, that is, a production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid: <CHEM> (wherein the ring A means the basic antibiotic; R<10> means a protected functional group used in organic synthesis; Ak-E means the alkali earth metal; and B means the inorganic acid, respectively); a novel oxalate useful as a production intermediate for producing an antibiotic.hydrochloride industrially, that is, an oxalate (II-I) of a carbapenem compound represented by the following formula: <CHEM> (wherein the ring A represents a 3- to 7-membered ring having at least one nitrogen atom, and the ring A may be substituted with other than R<6>; R<1> represents hydrogen or methyl group; R<2> and R<5> are the same as or different form each other and each represents hydrogen or a hydroxyl-protecting group; R<3> represents a carboxyl-protecting group; R<4> represents hydrogen, a lower alkyl group or an amino-protecting group; R<6> represents (1) hydrogen, (2) an optionally protected hydroxyl group, carbamoyl, formimidoyl, acetoimidoyl or a lower alkyl group which may be substituted with a substituent represented by the formula: <CHEM> (wherein R<7> and R<8> are the same as or different from each other and each represents hydrogen, a lower alkyl group or an amino-protecting group) or (3) an amino-protecting group or an imino-protecting group; and m is 0 or 1); and a process for producing its.</p> |
申请公布号 |
DE60014390(D1) |
申请公布日期 |
2004.11.04 |
申请号 |
DE2000614390 |
申请日期 |
2000.07.27 |
申请人 |
EISAI CO., LTD. |
发明人 |
KAYANO, AKIO;CHIBA, HIROYUKI;NAKAMURA, TAIJU;SAKURAI, SHIN;ISHIZUKA, HIROYUKI;SAITO, HIROYUKI;KOMATSU, YUUKI;SASHO, MANABU;SATO, NOBUAKI;NEGI, SHIGETO |
分类号 |
C07D477/02;C07D477/08;C07D477/20;C07D499/68;C07D501/22;C07D501/36;C07D501/46;(IPC1-7):C07D477/02;C07D499/00;C07D463/00;C07D501/00 |
主分类号 |
C07D477/02 |
代理机构 |
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主权项 |
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地址 |
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