| 摘要 |
The hyperthermic treatment is applied to synthesis vascular smooth muscle cells that have undergone the growth stimulation, whereby only the abnormal growth is selectively inhibited without having an adverse effect on the surrounding normal cells. The timing of the hyperthermic treatment is preferably after the growth stimulation, more preferably 2 hours after the growth stimulation. The hyperthermic treatment temperature is preferably in the range of from 42° C. to 44° C., and 43° C. is optimal. The hyperthermic treatment time is preferably in the range of from 90 to 180 minutes, and 120 minutes is optimal. Outside the ranges of the hyperthermic treatment conditions, the growth inhibition effect might be insufficient, the normal contraction type smooth muscle cells might be brought to cell death, or the growth of the vascular endothelial cells might be inhibited. The hyperthermic treatment is a safe therapy with less pain to patients, which can be clinically applied as a method for hindering restenosis after coronary lesion angioplasty.
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