发明名称 |
COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS |
摘要 |
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; m is 2 or 3; q is 0 or 1; t is 0 or 1; R<2> is alkyl having from 1 to 3 carbon atoms; R<3> is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I by a ring carbon; and R<1> is hydrogen or alkyl having 1 or 2 carbon atoms. Alternatively, when R<1> is hydrogen, the biologically active agent can be a pharmaceutically acceptable salt of the compound of Formula (I). |
申请公布号 |
WO2004093806(A2) |
申请公布日期 |
2004.11.04 |
申请号 |
WO2004US12142 |
申请日期 |
2004.04.20 |
申请人 |
WELLSTAT THERAPEUTICS CORPORATION;HODGE, KIRVIN, L.;KAUFMAN, ROBERT, J.;LEE, ALBERT;SHARMA, SHALINI;VON BORSTEL, REID, W. |
发明人 |
HODGE, KIRVIN, L.;KAUFMAN, ROBERT, J.;LEE, ALBERT;SHARMA, SHALINI;VON BORSTEL, REID, W. |
分类号 |
A01N43/12;A61K;C07C63/00;C07C69/734;C07C205/00;C07C229/00 |
主分类号 |
A01N43/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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