| 摘要 |
A medical device, such as a stent, for delivering a therapeutic agent to body tissue of a patient and a method of making such a medical device are disclosed. The medical device comprises a surface, a first coating layer comprising a biological activator such as a transfection agent adhering to at least a portion of the surface, and a second coating layer comprising a therapeutic agent disposed over at least a portion of the first coating layer. The transfection agent enhances the delivery of the therapeutic agent to the targeted body tissue, and reduces the surface tension of the surface of the medical device. The transfection agent may be a poloxamer and the therapeutic agent may be a genetic material. The disclosed method allows for greater efficiency in applying the therapeutic agent onto the medical device surface and enhances delivery of the therapeutic agent to the targeted body tissue.
|
