The invention provides for a polyvalent protein complex (PPC) comprising two polypeptide chains generally arranged laterally to one another. Each polypeptide chain typically comprises 3 or 4 "v-regions", which comprise amino acid sequences capable of forming an antigen binding site when matched with a corresponding v-region on the opposite polypeptide chain. Up to about 6 "v-regions" can be used on each polypeptide, chain. The v-regions of each polypeptide chain are connected linearly to one another and may be connected by interspersed linking regions. When arranged in the form of the PPC, the v-regions on each polypeptide chain form individual antigen binding sites.
申请公布号
WO2004094613(A2)
申请公布日期
2004.11.04
申请号
WO2004US12662
申请日期
2004.04.22
申请人
IBC PHARMACEUTICALS;IMMUNOMEDICS, INC;ROSSI, EDMUND, A.;CHANG, CHIEN-HSING;MCBRIDE, WILLIAM, J.
发明人
ROSSI, EDMUND, A.;CHANG, CHIEN-HSING;MCBRIDE, WILLIAM, J.