MODEL FOR NEURODEGENERATIVE DISORDERS

摘要

The present invention discloses a double transgenic fly that expresses both human Tau protein and the human Abeta42 peptide of human amyloid-beta precursor protein (APP). The double transgenic flies of the present invention display a synergistic altered phenotype as compared to the altered phenotype displayed by transgenic flies expressing either human Tau or human Abeta42 alone. Thus, the flies provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying therapeutic compounds to treat neurodegenerative disorders using the double transgenic flies.