USE OF STEROID DERIVATIVES FOR THE TREATMENT OF ANGIOTENSIN II RELATED DISEASE E.G. CARDIOVASCULAR AND PROLIFERATIVE DISORDERS

摘要

Use of a compound of formula (I) or a 3-enol C1 to 4 alkanoate ester thereof in the manufacture of a medicament for the treatment of an angiotensin II related disease in humans and animals wherein R1, R2, R5, R6 are the same or different and each is hydrogen or C1 to 4 alkyl; R3 is hydrogen, C1 to 4 alkyl, C2 to 4 alkenyl or C2 to 4 alkynyl; R4 is hydroxyl, C1 to 4 alkanoyloxy, a group of formula (II) or (III) wherein R7 is (CH2)n, where n is an integer of from 0 to 4, R8 is hydrogen, C 1 to 4 alkyl, hydroxy or NH2 and R9 and R10 are the same or different and each is hydrogen or C1 to 4 alkyl; or R3 and R4 together are oxo, ethylenedioxy or propylenedioxy.